What Is It?
GHK-Cu is a copper-bound tripeptide (glycyl-L-histidyl-L-lysine) that occurs naturally in the body and declines with age. In laboratory and early clinical research it has been evaluated for effects on skin remodeling, hair follicle activity, and tissue repair. In the United States, GHK-Cu is dispensed as a compounded prescription or as a cosmetic ingredient depending on the intended use, and it is not FDA-approved as a drug. Some providers use it topically or by injection as part of a broader plan supporting skin appearance, hair density, or tissue recovery goals in eligible adults.
What May It Support?
- Skin appearance (being evaluated)
- Hair follicle activity (being evaluated)
- Soft-tissue support (being evaluated)
- Adjunctive support alongside in-office cosmetic or regenerative services
Which Programs May Include It?
Where It Fits
Being evaluated for effects on collagen and extracellular matrix signaling, antioxidant activity, and copper delivery to tissues; the full human mechanism is not yet established.
Do I Need Bloodwork?
Follow-up interval and testing are determined by the treating provider based on the overall treatment plan.
Likely baseline panel may include: Provider-determined based on history and treatment goals
Important Safety Information
Common side effects may include:
- Local irritation or redness at application site (topical use)
- Injection-site reactions (injectable use)
- Occasional blue tinting at the injection or application site (copper content)
- Rare allergic reaction
Excess copper exposure can be harmful; do not exceed provider-directed dosing
Not established for use during pregnancy or breastfeeding
Drug interactions: Interactions are not fully characterized. Disclose all prescription medications, over-the-counter products, supplements (especially those containing copper or zinc), and topical products to your provider before starting.
Contraindications:
- Wilson's disease or other copper-metabolism disorders
- Known copper hypersensitivity
- Pregnancy or breastfeeding
- Open uncontrolled wound infection at the application site
Regulatory Status
GHK-Cu is not FDA-approved as a drug for any indication. When prescribed by a licensed medical provider, it is dispensed as a compounded prescription.
Frequently Asked Questions
Is GHK-Cu the same as the copper peptide in skincare?
Can I combine GHK-Cu with retinol or other topicals?
Do I need bloodwork before starting?
Is GHK-Cu safe for hair?
Consultation
Treatment is not automatically provided. A licensed medical provider must review your history, symptoms, medications, laboratory results, and treatment goals before determining eligibility.