What Is It?
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every cell of the body and central to energy metabolism, mitochondrial function, and DNA-repair signaling. NAD+ levels typically decline with age. When prescribed by a provider, NAD+ may be given as an intravenous (IV) infusion, subcutaneous injection, or intramuscular injection as a compounded therapy. Some providers use NAD+ as part of a broader plan supporting energy, cognitive complaints, or healthy-aging goals in eligible adults, always under monitoring.
What May It Support?
- Cellular energy support (being evaluated)
- Cognitive complaints such as brain fog (being evaluated)
- Healthy-aging support (being evaluated)
- Adjunctive support in a broader wellness plan
Which Programs May Include It?
Where It Fits
Provides substrate for pathways that generate ATP, drive mitochondrial function, and support DNA-repair enzymes such as sirtuins and PARPs; the clinical impact of supplemental NAD+ in humans is still being characterized.
Do I Need Bloodwork?
Follow-up interval and any additional testing are determined by the treating provider.
Likely baseline panel may include: Recent CBC, CMP, and a general wellness panel recommended
Important Safety Information
Common side effects may include:
- Flushing or warmth during infusion
- Chest tightness or shortness of breath during rapid infusion (typically resolves when slowed)
- Nausea
- Injection-site reactions
- Headache
Long-term safety data in humans at supra-physiologic doses is limited
Not established for use during pregnancy or breastfeeding
Drug interactions: Interactions are not fully characterized. Disclose all prescription medications, over-the-counter products, and supplements to your provider before starting.
Contraindications:
- Known hypersensitivity to NAD+ or component excipients
- Any condition the provider determines is inappropriate for infusion or injection therapy
- Pregnancy or breastfeeding
Regulatory Status
NAD+ is not FDA-approved as a drug for anti-aging, energy, or cognitive indications. When prescribed by a licensed medical provider, it is dispensed as a compounded therapy.
Frequently Asked Questions
How is NAD+ given?
Do I need bloodwork before starting?
How quickly will I feel a difference?
Is NAD+ safe with my current medications?
Consultation
Treatment is not automatically provided. A licensed medical provider must review your history, symptoms, medications, laboratory results, and treatment goals before determining eligibility.